According to Ayurveda, the seat of the disease is in the brain and the psyche of the person is affected and so are the channels carrying impulses (they were probably referring to the nerves). Besides Vata dominant physical doshas and Raj and Tam mental doshas are known to be the causative factors.
|Dosha||Vata dominant physical doshas.|
|Raj and Tam mental doshas.|
|Dushya||Psyche (Mann – mental state)|
|Srotas||Manovaha srotas (Channels carrying impulses)|
|Location||Brain (Seat of intellect – Mind)|