BONE & JOINT DISORDERS (ARTHRITIS)
GOUT – WHAT HAPPENS
Uric acid is a substance that results from the breakdown of purines. Typically, uric acid is dissolved in the blood and discarded from the body through the kidney into the urine. Normally the blood level of monosodium urate is 7mg/dl.
If due to any reason the kidneys are unable to eliminate uric acid or the body increases its production of uric acid, the levels go high and result in a condition called as hyperuricemia. Prolonged elevation of blood urate levels causes deposition of uric acid crystals (monosodium urate monohydrate) in the connective tissues and joint spaces resulting in inflammation. This leads to extreme pain, redness, swelling in the joint. Deposition of uric acid can appear as lumps under skin around the joints, these are called ‘tophi’.
As the disease progresses, the uric acid crystals may also deposit in the kidneys resulting in kidney stones.