This is one of the most extensive clinical research study done in order to find out the possible risk factors for heart diseases. This elaborate study was started in 1949 under the able guidance of Dr. William Castelli. This study includes every person of age group 30 – 62 years, residing at Framingham town of Massachusetts. Overall 5,209 participants are selected for the research work.

These studies revealed that high blood pressure, elevated blood cholesterol (hypercholestremia), obesity and cigarette smoking has a direct positive correlation with incidence of heart diseases. However, the beneficial effect of regular physical exercises is also proved.

In the continuation of this study, a supplementary study was initiated in 1972 to find out the hereditary component for heart diseases. Some dietary practices are also included this time for the evaluation.