According to a new study report, even very low dosage of aspirin taken regularly can increase the bleeding risk. The study results are very important because due to its potential benefits aspirin is frequently used for preventing heart attacks.
The findings also suggest that in terms of causing bleeding problems, moderate aspirin doses may be just as bad as high doses. Moreover, moderate doses significantly increase the risk of stomach bleeding and stroke compared with low doses.
The study researchers analyzed data from 31 clinical trials (involved 192,036 patients) of aspirin. The patients can be divided into three groups depending on their daily aspirin dosage:
1) Low (less than 100 mg)
2) Moderate (100-200 mg)
3) High (more than 200 mg)
The final study report showed that the rate of bleeding problems ranged from 3.7% in the low-dose group to 11.3% in the moderate group. The high dose group had a rate of 9.8%, which although lower was statistically comparable to the rate in the moderate-dose group.
The rate of fatal or life-threatening bleeding problems in the low-moderate and high dose group was reported to be .27, .46 and 1.59% respectively. It indicates that doses over 100 mg are comparable to 300 mg in the terms of bleeding risk and other potential side effects. Moreover, these study findings are very important because in most of the countries the standard recommended to heart patients is 150 mg.