Some researches have reported that high protein diet may lead to higher levels of homocystein (a by–product of protein metabolism and an independent risk factor for heart disease). Although it has been shown that people with higher blood levels of homocysteine are at greater risk for heart disease.  Homocysteine is produced during the protein metabolism in the body and then removed from the bloodstream by the kidneys. The body’s ability to keep homocysteine levels in check may be impaired when a person is taking high protein diet as this diet pattern exerts extra burden on kidneys. This could lead to a higher risk of heart diseases.