RABIES VACCINE – Pre-Exposure Immunization
Anti Rabies vaccine is indicated for high-risk groups so that these individuals have some protection if they come in contact with an infected animal. This group includes:
- Veterinarians (a large animal practice probably provides more risk than a small animal clinic).
- Animal handlers
- Certain lab workers.
- Persons living in countries where rabies is a threat.
- Persons who work with potentially rabid animals – zookeepers, trappers etc.
Dosage and schedule
- 3 doses of pre-exposure vaccine is given IM(Intramuscular) or ID (Intradermal) on 0, 7th, and 28thday.
- Booster doses of vaccine are recommended every 1 – 3 years for individuals who continue to be at increased risk of contracting rabies and whose rabies antibody titer is less than 0.5 IU/ml.
Repeat booster doses increase the risk of allergic reaction to rabies vaccine by 6%. Therefore, a titer is recommended prior to receiving a booster dose of rabies HDCV vaccine. If the titer is 0.5 IU/ml or greater, a booster dose is not indicated. A titer should be repeated again in two years.
Pre-exposure Immunization Time Table
The 3 choices available are:
|Vaccine||Dose||Number of Doses||Schedule (Days)||Route|
|HDCV||0.1 ml||3||0, 7, 28 or 0, 28, 56.||Intradermal|
|HDCV||1.0 ml||3||0, 7, 28 or 0, 28, 56.||Intramuscular|
|PCEC||1.0 ml||3||0, 7, 28 or 0, 28, 56.||Intramuscular|