Cyclosporin A

Cyclosporin is the mainstay of therapy used to prevent immediate as well as long-term rejection of transplanted kidneys.

  • Action
    • It prevents rejection by inhibiting the T lymphocytes (special type of cells of the immune system which help to fight off any foreign invaders)
  • How to take
    • Cyclosporin may be taken in oral or injection form. Oral cyclosporin is available in capsules and liquid form. The medicine should be kept at room temperature away from direct sunlight.
    • Use a glass container for taking liquid cyclosporin.
    • Avoid taking meal, grape fruit or juice, pineapple juice with cyclosporin.
    • If the patient is not able to take cyclosporin orally due to any reason (such as inability to swallow, vomiting), it can be given intravenously.
  • Precautions
    • Liquid cyclosporin should be used within 2 months of opening the bottle. Its a good idea to date the bottle when you open it.
    • Many medicines can hamper the absorption of cyclosporin, hence always consult your doctor before taking any other medication.
    • Do not take high doses of aspirin or NSAIDs while taking cyclosporin.
    • Do not use oral contraceptive pills while taking cyclosporin.
  • Side effects Cyclosporin is usually well tolerated by the patients but it may produce the following side effects:
    • Acute kidney failure
    • High blood pressure
    • Resting tremor (trembling)
    • Increased hair growth (Hirsutism)
    • Swollen gums (Gum hyperplasia)
    • Post-transplant diabetes
    • Increased cholesterol levels (hyperlipidemia)