Tacrolimus (FK-506)

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Tacrolimus is a potent immunosuppressive agent used to prevent transplant rejection.

  • How to take
    • Tacrolimus is taken by mouth. Intravenous Tacrolimus is highly toxic and is not recommended. It can be given through a nasogastric tube if the patient is not able to take it orally.
  • Precautions
    • Magnesium oxide, sodium bicarbonate, Sucralfate or other antacids should not be taken within two hours of taking Tacrolimus.
  • Side effects
    • When given in high doses (for treating¬† rejection) it can cause tremors, burning and tingling in mouth, hands or feet; headache and insomnia (loss of sleep). These usually disappear with the reduction in dose.
    • Nausea and vomiting
    • High blood sugar
    • High blood pressure
    • Increased potassium levels in blood