A new study reports indicate that high doses of NSAIDs (Non-Steroidal Anti Inflammatory Drugs) and COX-2 inhibitors significantly increases the risk of heart attacks in arthritis patients. These results further confirm that the selection of pain killers should be based on their relative gastrointestinal and cardiovascular safety. In this study, the researchers observed the risk of heart attack in more than 650,000 adults diagnosed with arthritis and treated with NSAIDs or selective COX-2 inhibitors between January 1999 to June 2004.the study results revealed that many (but not all) NSAIDs such as indomethacin, sulindac and ibuprofen increases the risk of heart attack by 71%, 41% and 11% respectively. Among coxibs rofecoxib increased the risk by 32% and celecoxib by 9%. Moreover, the risk of heart attack appeared to be dose-dependent. For example, rofecoxib increased the risk from 16% at daily doses of 12.5mg to 240% at daily doses over 50 mg. The results further emphasized that the physicians/doctors need to consider individual patients risks and concerns related to the cardiovascular system and the other areas where the NSAIDs and coxibs are known to have an impact especially the stomach, liver and kidneys.