What happens

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According to Ayurveda, the seat of the disease is in the brain and the psyche of the person is affected and so are the channels carrying impulses (they were probably referring to the nerves). Besides Vata dominant physical doshas and Raj and Tam mental doshas are known to be the causative factors.

Dosha Vata dominant physical doshas.
Raj and Tam mental doshas.
Dushya Psyche (Mann – mental state)
Srotas Manovaha srotas (Channels carrying impulses)
Location Brain (Seat of intellect – Mind)